In the photo the most distinctive parts of the skyline, apart from the cranes, are the Palazzo Vecchio with its tower, and just right and behind it - the dome of the Duomo. The viewpoint is just west, and on the south side of, the Ponte alla Grazie.
The next picture was taken from the via dei Pecori looking into the Piazza del Duomo.
And this one is a closer view of the Palazzo Vecchio.
And the statue of Cosimo di Medici which stands in front of the Palazzo Vecchio.